Manplus counteract the side effects of certain products, Estrogen induces lipogenesis (lipid synthesis and inhibits the muscle or cerebral activity of Strength Muscles. Actually the very opposite of what a bodybuilding practitioner is looking for. Age also increases the activity of this enzyme so obviously this can cause more problems like certain cancers in particular the famous prostate cancer. Prostate cancer is actually, in fact, a gradual increase in the volume of the prostate, resulting in obstruction of the urinary stream. .